Mouthwatering Meatloaf Sandwich Recipe – Easy and Delicious!

Welcome to my kitchen, where I specialize in southern-style cuisine. Today, I want to share with you my all-time favorite sandwich recipe: the Southern-Style Meatloaf Sandwich.

This sandwich is the perfect way to enjoy the flavor and comfort of classic southern meatloaf in a convenient and satisfying format. It’s the kind of meal that will leave you feeling warm and fulfilled from the first bite to the last.

The combination of juicy ground beef, bell peppers, onions, ketchup, and Worcestershire sauce makes for a tangy and savory meatloaf that pairs perfectly with bread and butter pickles on soft white bread. The result is a delicious sandwich that is both hearty and flavorful.

Whether you’re looking for an easy lunch or an indulgent dinner, this recipe is sure to please. So let’s get started and learn how to make this mouth-watering southern meatloaf sandwich.

Why You’ll Love This Recipe

Southern-Style Meatloaf Sandwich
Southern-Style Meatloaf Sandwich

There’s something irresistible about a good southern-style meatloaf sandwich. It’s the ultimate comfort food, perfect for any time of day, and will leave you craving for more. This meatloaf sandwich recipe is incredibly easy to make, using simple, everyday ingredients that are likely already in your pantry. But don’t let the simplicity of this sandwich fool you – it packs a punch of flavor that will transport your taste buds straight to the south!

If you’re a fan of classic meatloaf, then you’re going to love this southern-style version. What sets it apart from other recipes is the combination of ingredients that create a unique flavor and texture – from the juicy lean ground beef to the perfectly spiced ketchup sauce with a hint of Worcestershire sauce. The result is an incredibly satisfying and delicious meal that can be made with leftovers or fresh meatloaf.

One thing I love about this recipe is its versatility. You can serve it up as an open-faced sandwich or as a classic sandwich with a slice of bread on top. You can add some mozzarella cheese for extra indulgence, or some bread and butter pickles for a tangy finish. If you’re feeling adventurous, you can even fry up the meatloaf slice and turn it into a southern-style fried meatloaf sandwich!

Not only is this southern-style meatloaf sandwich delicious, but it’s also incredibly filling and satisfying. It’s perfect for a lazy Sunday brunch with family or friends, or as a quick weekday dinner when you need something hearty and tasty. Plus, with the simple ingredient list and easy-to-follow instructions, even those who are not experienced in the kitchen can whip this sandwich up with ease.

In short, if you want to experience the best that southern soul food has to offer, then try out this meatloaf sandwich recipe. Trust me; once you’ve made one batch, you’ll be hooked!

Ingredient List

 Sink your teeth into this hearty southern-style meatloaf sandwich!
Sink your teeth into this hearty southern-style meatloaf sandwich!

Let’s Gather Our Southern-Style Meatloaf Sandwich Recipe Ingredients

Before we get started with this finger-licking sandwich recipe, let’s make sure we have all the ingredients we need. Here is what you will need for our southern-style meatloaf sandwich:

  • 1 ½ lbs lean ground beef (You can also substitute half of the ground beef for ground pork if you prefer)
  • 2/3 cup bread crumbs
  • 1 small onion, chopped finely
  • 1 small bell pepper, chopped finely
  • ¾ cup ketchup
  • ¼ cup worcestershire sauce
  • 2 large eggs, beaten
  • Salt and freshly cracked pepper to taste

For the sandwich assembly:

  • Bread and butter pickles
  • Mozzarella cheese slices (you can also use cheddar or provolone)
  • Soft hamburger buns (or your favorite bread)
  • Butter for toasting buns
  • Ketchup and mustard (optional)

The great thing about this recipe is that most of these ingredients are probably already in your kitchen! If not, you can easily find them in any grocery store. Get ready to cook up some soulful meatloaf and make the best leftover meatloaf sandwiches ever!

The Recipe How-To

 A meatloaf sandwich that will bring you back home to the south.
A meatloaf sandwich that will bring you back home to the south.

Now that you have gathered all the ingredients, it’s time to start cooking your Southern-Style Meatloaf Sandwich. Follow these steps carefully for a perfectly put-together meal.

Mixing and Prepping

  1. Begin by preheating your oven to 350°F (180°C).

  2. Put 1 lb of lean ground beef and 1/2 lb of ground pork into a large mixing bowl.

  3. Add in 3/4 cup of breadcrumbs, 1/2 cup of milk substitute, 1/4 cup of finely chopped onion, 1/4 cup of finely chopped bell pepper, and 2 cloves of garlic, minced.

  4. Mix thoroughly until everything is well-combined.

  5. Then pour in 1 egg, 1/2 cup of ketchup, 1 tablespoon of Worcestershire sauce and season with salt and pepper to taste.

  6. Mix together until everything is fully incorporated.

  7. Form the mixture into a meatloaf shape and transfer it onto a small shallow dish or bowl.

  8. Add about half-inch water to the dish in order to prevent the meatloaf from sticking during cooking.

  9. Bake for about an hour, or until done, then let cool on a wire rack for about ten minutes before slicing.

Assembling the Sandwiches

  1. While the Meatloaf is cooking, prepare the Bread and Butter Pickles Spread by mixing together 2 tablespoons of butter, 3 tablespoons of ketchup, 3 tablespoons of bread and butter pickles (finely chopped) and set aside.

  2. Once your Meatloaf has finished cooking and resting, cut it with a serrated knife into half-inch slices.

  3. Heat a frying pan over medium-high heat with some oil, place each slice flat onto the pan and cook each side for 2-3 minutes, or until browned and slightly crispy.

  4. Place one slice of bread on a plate, add a meatloaf slice on top, then cover with the Bread and Butter Pickles Spread.

  5. Sprinkle some shredded mozzarella cheese over the top and place under the broiler until cheese has melted.

  6. Add another slice of bread if you like or leave it as an open-faced sandwich.

  7. Enjoy your delicious Southern-Style Meatloaf Sandwich!

Substitutions and Variations

 A sandwich fit for a southern feast!
A sandwich fit for a southern feast!

As a chef, I understand the importance of being able to tweak a recipe to suit one’s taste or dietary needs. Thus, I’ve come up with some suggested substitutions and variations for our Southern-Style Meatloaf Sandwich recipe.

For those who want to cut down on red meat, swap out half of the ground beef for ground pork. This substitution will add a little more moisture and flavor to the meatloaf, making it extra delicious.

If you’re lactose intolerant, using mozzarella cheese might not agree with your stomach. No problem! Instead of topping your sandwich off with cheese, try slathering on some avocado mayo or hummus for added creaminess.

For a healthier twist on this classic dish, substitute regular bread crumbs for Panko bread crumbs. Panko is lighter and less dense than traditional breadcrumbs and will result in a lighter textured meatloaf.

Feeling adventurous? Fry up a leftover meatloaf slice for an extra-crispy fried meatloaf sandwich. It’s like taking two comfort foods and combining them into one dish that will surely satisfy any craving.

You can also experiment with different condiments like mustard or BBQ sauce instead of ketchup or add diced bell peppers to the mix for more aroma and texture.

Remember, cooking is all about having fun and being creative in the kitchen. Feel free to explore different options based on your preferences and enjoy your unique take on this classic Southern-style meal.

Serving and Pairing

 This ain't your average sandwich, y'all!
This ain’t your average sandwich, y’all!

Once your southern-style meatloaf sandwich is ready, it’s time to pair it with the perfect side dish and drink. I recommend serving this sandwich with a side of crispy French fries or a simple side salad. The fried texture of the French fries complements the juicy and savory flavor of the sandwich, while a light and refreshing salad adds a fresh contrast to each bite.

As for the drink, I suggest a cold glass of sweet iced tea or an ice-cold beer. The sweetness of the tea and boldness of beer perfectly balance out the richness of the sandwich. If you prefer something non-alcoholic, lemonade or soda are great alternatives.

One popular way to serve this sandwich is as an open-faced sandwich. Simply place a slice of meatloaf on top of a slice of bread or brioche bun, then add a dollop of ketchup or mustard sauce on top. Melt some mozzarella cheese over it in the oven, then garnish with finely chopped bell peppers and bread and butter pickles for added texture and tanginess.

This southern-style meatloaf sandwich is perfect for lunch, dinner, or even as a midnight snack. It’s hearty enough to fill you up but not too heavy that you feel weighed down. This versatile meal also makes for great leftovers – simply reheat in the oven or microwave and enjoy once again!

Make-Ahead, Storing and Reheating

 Put some south in your mouth with this delicious meatloaf sandwich!
Put some south in your mouth with this delicious meatloaf sandwich!

Now that you’ve made the perfect meatloaf sandwich, what should you do with any leftovers? No problem – this sandwich is just as delicious the next day. Here are some tips for storing and reheating:

Make-Ahead: If you like to meal prep, you can make the meatloaf in advance and store it in an airtight container in the refrigerator for up to three days. You can also freeze the meatloaf for up to three months. When you’re ready to assemble your sandwiches, simply take out the meatloaf and let it thaw in the refrigerator overnight.

Storing: Once assembled, place any uneaten sandwiches in an airtight container or wrap them tightly with plastic wrap. Store them in the refrigerator for up to three days.

Reheating: Reheating your meatloaf sandwiches is easy! You can use a microwave or a toaster oven. To use the microwave, remove any plastic wrap and place one sandwich on a microwave-safe plate. Heat it for 30 seconds at a time until it’s heated through. To use the toaster oven, preheat the oven to 350°F (175°C). Place your sandwich on a baking sheet and toast for about 5-10 minutes until it’s heated through.

Remember that when reheating bread items, it’s essential to monitor it closely so it doesn’t become too dry or crispy. Once reheated, top with fresh ingredients like butter, bread and butter pickles and ketchup, as desired.

Now that you know how to store and reheat your meatloaf sandwiches, making them ahead of time has never been easier! Give yourself one less thing to worry about during busy weeknights by prepping some sandwiches for an easy lunch or diner.

Tips for Perfect Results

 You can taste the southern charm in every bite of this meatloaf sandwich.
You can taste the southern charm in every bite of this meatloaf sandwich.

As a chef specializing in southern-style cuisine, I know a thing or two about making the perfect meatloaf sandwich. Here are some tips to help you achieve the best results:

First and foremost, use high-quality ingredients. Start with lean ground beef and pork, fresh bread crumbs, and finely chopped onions and bell peppers. This will ensure that your meatloaf has the best flavor and texture possible.

When mixing together the meatloaf ingredients, be careful not to overwork the mixture. Overmixing can cause the meatloaf to become tough and dry.

To make sure your meatloaf is moist and tender, mix in a small amount of milk substitute or water before baking. This will help keep the meatloaf from drying out during cooking.

If you’re using leftover meatloaf for your sandwich, consider frying it up for added texture and flavor. Simply slice the leftover meatloaf into thick slices, dredge in seasoned flour, and fry in butter until crispy.

When assembling your sandwich, be generous with the sauce. A mixture of ketchup, mustard, Worcestershire sauce, and butter makes for a deliciously tangy and slightly sweet topping.

Finally, choose your bread wisely. The best bread for a meatloaf sandwich is soft yet sturdy enough to hold up against the weight of the filling. Bread and butter pickles make for a great addition as well.

Follow these tips and you’ll be well on your way to creating the perfect southern-style meatloaf sandwich every time.


Now that you have learned the ins and outs of crafting a delicious southern-style meatloaf sandwich, you may still have some questions. Don’t worry; we have got you covered with some frequently asked questions about this recipe. Whether you are curious about ingredient substitutions or want to know how long you can store the leftovers for optimal taste, we have addressed several common inquiries in this section. So, let’s get started!

Why do you put milk in meatloaf?

The addition of milk in meatloaf serves the purpose of moistening the bread crumbs. However, individuals who prefer alternatives to milk can opt for low sodium beef stock, chicken stock, water or non-dairy substitutes.

Why is meatloaf so good?

Meatloaf is a delicious dish that combines different elements such as starch, vegetables, and meat. According to Bruni, this mixture of robust flavors in one form is what makes meatloaf irresistible.

What style of food is meatloaf?

Meatloaf has a rich cultural history, with roots tracing back to traditional dishes enjoyed in Germany, Scandinavia, and Belgium. Interestingly, its American counterpart has ties to scrapple, a cornmeal and ground pork mixture that German-Americans in Pennsylvania have been enjoying since colonial times. This hearty and flavorful meal has become a beloved staple in Southern cuisine, and today, I’ll be sharing my recipe for a delicious and classic meatloaf.

Bottom Line

In conclusion, this Southern-Style Meatloaf Sandwich recipe is a perfect choice for anyone who loves savory and delicious sandwiches. With its flavorful meatloaf, tangy ketchup, buttery bread, and zesty pickles, this sandwich is quintessentially Southern comfort food that can be enjoyed at any time of the day.

Whether you’re craving a delicious lunch or looking for a satisfying dinner option, this recipe has got you covered. Plus, with the easy-to-follow steps and customizable ingredient list, you can make it your own and create a sandwich that perfectly fits your taste.

So why not try this recipe out today and see what all the fuss is about? It’s sure to become your go-to sandwich recipe in no time!

Southern-Style Meatloaf Sandwich

Southern-Style Meatloaf Sandwich Recipe

A popular southern way to make meatloaf sandwiches is to use butter or margarine instead of mayo. This great sandwich is a favorite for lunches and picnics. You can add lettuce, if you like, but it's good without "adornment".
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Prep Time 5 mins
Cook Time 0 mins
Course Main Course
Cuisine American
Calories 337 kcal


  • 1 slice of leftover meatloaf, thick, straight from the fridge
  • ketchup, drizzled over slice
  • bread and butter pickles
  • 2 slices bread, I like white bread
  • butter
  • salt and pepper


  • Slather both slices of bread with butter.
  • Add the meatloaf slice and additional seasonings.
  • Cut in half and pack in a lunch or eat right away!

Add Your Own Notes


Serving: 135gCalories: 337kcalCarbohydrates: 25.3gProtein: 25.9gFat: 13.8gSaturated Fat: 5gCholesterol: 77.3mgSodium: 394.9mgFiber: 1.2gSugar: 2.1g
Keyword < 15 Mins, Easy, Lunch, Meat
Tried this recipe?Let us know how it was!

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